Varaico: Literature-Extracted Genetic Variants

LYN

213 papers

RefSeq Summary

This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding differ...

Pfam Domains

SH3_1aa 69–115UCSCSH3 domain

SH2aa 129–211UCSCSH2 domain

PK_Tyr_Ser-Thraa 247–497UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LYN proto-oncogene, Src family tyrosine kinase

HGNC Alias Symbol

JTK8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002350.4

p.K120I

c.359A>T

Surrounding Variants

1 paper

NM_002350.4

p.L121R

c.362T>G

1 paper

NM_002350.4

p.V118M

c.352G>A

1 paper

NM_002350.4

p.E125Q

c.373G>C

1 paper

NM_002350.4

p.E125*

c.373G>T

1 paper

NM_002350.4

p.E128V

c.383A>T

1 paper

NM_002350.4

p.E110fs

c.328_329fs

1 paper

NM_002350.4

p.K109delFs

c.327delA

1 paper

NM_002350.4

p.L106I

c.316T>A

6 papers

NM_002350.4

p.L105L

c.315T>A

1 paper

NM_002350.4

p.S104F

c.311C>T

1 paper

NM_002350.4

p.H96L

c.287A>T

1 paper

NM_002350.4

p.W129*

c.386G>A