Varaico: Literature-Extracted Genetic Variants

LYN

213 papers

RefSeq Summary

This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding differ...

Pfam Domains

SH3_1aa 69–115UCSCSH3 domain

SH2aa 129–211UCSCSH2 domain

PK_Tyr_Ser-Thraa 247–497UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

LYN proto-oncogene, Src family tyrosine kinase

HGNC Alias Symbol

JTK8

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_002350.4

p.Y508H

c.1522T>C

Surrounding Variants

8 papers

NM_002350.4

p.Y508F

c.1523A>T

4 papers

NM_002350.4

p.Y508*

c.1524C>A

4 papers

NM_002350.4

p.Y508*

c.1524C>G

1 paper

NM_002350.4

p.Q507*

c.1519C>T

1 paper

NM_002350.4

p.A503D

c.1508C>A

1 paper

NM_002350.4

p.D498fs

c.1492_1493fs

1 paper

NM_002350.4

p.Q494*

c.1480C>T

2 papers

NM_002350.4

p.R487K

c.1460G>A

1 paper

NM_002350.4

p.R487T

c.1460G>C

1 paper

NM_002350.4

p.C479G

c.1435T>G

1 paper

NM_002350.4

p.M478I

c.1434G>A

1 paper

NM_002350.4

p.M478I

c.1434G>C