Varaico: Literature-Extracted Genetic Variants

MAP3K11

124 papers

RefSeq Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK k...

Pfam Domains

SH3_9aa 48–101UCSCVariant SH3 domain

PK_Tyr_Ser-Thraa 117–376UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 11

HGNC Previous Symbols

MLK3; PTK1

Papers

RefSeq ID

Protein change

DNA change

1–12 of 116 variants

4 papers

NM_002419.4

p.L410P

c.1229T>C

3 papers

NM_002419.4

p.K144R

c.431A>G

3 papers

NM_002419.4

p.R730H

c.2189G>A

2 papers

NM_002419.4

p.I176V

c.526A>G

2 papers

NM_002419.4

p.P252H

c.755C>A

2 papers

NM_002419.4

p.P469A

c.1405C>G

2 papers

NM_002419.4

p.S570F

c.1709C>T

2 papers

NM_002419.4

p.P606delFs

c.1816delG

2 papers

NM_002419.4

p.T680P

c.2038A>C

2 papers

NM_002419.4

p.A684T

c.2050G>A

2 papers

NM_002419.4

p.A684V

c.2051C>T

2 papers

NM_002419.4

p.R747C

c.2239C>T