Varaico: Literature-Extracted Genetic Variants

MAP3K11

124 papers

RefSeq Summary

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK k...

Pfam Domains

SH3_9aa 48–101UCSCVariant SH3 domain

PK_Tyr_Ser-Thraa 117–376UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase 11

HGNC Previous Symbols

MLK3; PTK1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002419.4

p.D357Splc

c.1069+10C>T

Surrounding Variants

1 paper

NM_002419.4

p.A356V

c.1067C>T

1 paper

NM_002419.4

p.A352T

c.1054G>A

1 paper

NM_002419.4

p.C358Y

c.1073G>A

1 paper

NM_002419.4

p.E314K

c.940G>A

1 paper

NM_002419.4

p.W399L

c.1196G>T

1 paper

NM_002419.4

p.W399C

c.1197G>T

1 paper

NM_002419.4

p.W399C

c.1197G>C

1 paper

NM_002419.4

p.E402Q

c.1204G>C

1 paper

NM_002419.4

p.G405R

c.1213G>C

1 paper

NM_002419.4

p.D408N

c.1222G>A

1 paper

NM_002419.4

p.D408D

c.1224C>T

4 papers

NM_002419.4

p.L410P

c.1229T>C