Varaico: Literature-Extracted Genetic Variants

Gene:MAP4K4
Variant:p.R43Q

MAP4K4

220 papers

RefSeq Summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is fou...

Pfam Domains

Pkinaseaa 25–289UCSCProtein kinase domain
CNHaa 1080–1354UCSCCNH domain

Gene Aliases

HGNC Name

mitogen-activated protein kinase kinase kinase kinase 4

HGNC Alias Symbols

HGK; NIK; FLH21957

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
2 papers
NM_001395002.1
p.R43Q
c.128G>A
Surrounding Variants
2 papers
NM_001395002.1
p.H44L
c.131A>T
1 paper
NM_001395002.1
p.G42V
c.125G>T
1 paper
NM_001395002.1
p.T47T
c.141G>A
1 paper
NM_001395002.1
p.L50M
c.148T>A
7 papers
NM_001395002.1
p.K54R
c.161A>G
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."