Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

191 papers

NM_000245.4

p.N375S

c.1124A>G

Surrounding Variants

14 papers

NM_000245.4

p.N375K

c.1125C>A

18 papers

NM_000245.4

p.N375K

c.1125C>G

2 papers

NM_000245.4

p.F374L

c.1122C>A

2 papers

NM_000245.4

p.F374L

c.1122C>G

2 papers

NM_000245.4

p.K376R

c.1127A>G

7 papers

NM_000245.4

p.K376K

c.1128G>A

1 paper

NM_000245.4

p.F374I

c.1120T>A

2 papers

NM_000245.4

p.F374L

c.1120T>C

8 papers

NM_000245.4

p.I377I

c.1131C>T

9 papers

NM_000245.4

p.V378I

c.1132G>A

1 paper

NM_000245.4

p.V378A

c.1133T>C

4 papers

NM_000245.4

p.D372N

c.1114G>A