Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000245.4

p.S990R

c.2970C>A

Surrounding Variants

1 paper

NM_000245.4

p.S990R

c.2970C>G

13 papers

NM_000245.4

p.P991S

c.2971C>T

NM_001127500.3

p.P1009S

c.3025C>T

1 paper

NM_001127500.3

p.S1008N

c.3023G>A

1 paper

NM_001127500.3

p.S1008_T1010delFs

c.3024_3028del5

1 paper

NM_000245.4

p.S990fs

c.2968_2969fs

1 paper

NM_000245.4

p.S990R

c.2968A>C

1 paper

NM_000245.4

p.P991L

c.2972C>T

1 paper

NM_001127500.3

p.T1010delFs

c.3028delA

1 paper

NM_000245.4

p.P991P

c.2973A>T

2 papers

NM_000245.4

p.V989_T992delins

c.2967_2976delinsGGCAGTCCAA

3 papers

NM_000245.4

p.T992A

c.2974A>G

1 paper

NM_001127500.3

p.V1007_E1012delFs

c.3021_3036del16