Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_000245.4

p.E1009fs

c.3025_3026fs

Surrounding Variants

2 papers

NM_000245.4

p.E1009Fs

c.3025_3027delinsGFs

2 papers

NM_000245.4

p.E1009D

c.3027A>C

2 papers

NM_001127500.3

p.E1027E

c.3081A>G

NM_000245.4

p.E1009E

c.3027A>G

2 papers

NM_000245.4

p.E1009D

c.3027A>T

3 papers

NM_000245.4

p.D1010delFs

c.3028delG

6 papers

NM_000245.4

p.P1008_D1010delFs

c.3024_3028del5

NM_001127500.3

p.P1026_D1028delFs

c.3078_3082del5

1 paper

NM_000245.4

p.P1008fs

c.3022_3023fs

1 paper

NM_000245.4

p.P1008A

c.3022C>G

1 paper

NM_001127500.3

p.P1026S

c.3076C>T

1 paper

NM_000245.4

p.P1008_E1009delFs

c.3023_3026del4

51 papers

NM_001127500.3

p.D1028N

c.3082G>A

NM_000245.4

p.D1010N

c.3028G>A

66 papers

NM_000245.4

p.D1010H

c.3028G>C

NM_001127500.3

p.D1028H

c.3082G>C