Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_000245.4

p.K1199R

c.3596A>G

Surrounding Variants

2 papers

NM_000245.4

p.K1199T

c.3596A>C

1 paper

NM_000245.4

p.K1199M

c.3596A>T

1 paper

NM_000245.4

p.K1199fs

c.3595_3596fs

1 paper

NM_000245.4

p.K1199E

c.3595A>G

2 papers

NM_000245.4

p.K1199fs

c.3595_3596fs

1 paper

NM_000245.4

p.K1199N

c.3597G>C

1 paper

NM_000245.4

p.K1199N

c.3597G>T

23 papers

NM_000245.4

p.F1200I

c.3598T>A

6 papers

NM_000245.4

p.F1200L

c.3598T>C

3 papers

NM_000245.4

p.F1200V

c.3598T>G

2 papers

NM_000245.4

p.K1198I

c.3593A>T

1 paper

NM_000245.4

p.K1198E

c.3592A>G