Varaico: Literature-Extracted Genetic Variants

MET

3,492 papers

RefSeq Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and be...

Pfam Domains

Semaaa 317–493UCSCSema domain

PSIaa 519–562UCSCPlexin repeat

TIGaa 563–654UCSCIPT/TIG domain

TIGaa 657–739UCSCIPT/TIG domain

TIGaa 742–830UCSCIPT/TIG domain

PK_Tyr_Ser-Thraa 1078–1337UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

MET proto-oncogene, receptor tyrosine kinase

HGNC Alias Symbols

HGFR; RCCP2; DFNB97

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_001127500.3

p.D1249A

c.3746A>C

NM_000245.4

p.D1231A

c.3692A>C

Surrounding Variants

4 papers

NM_000245.4

p.D1231N

c.3691G>A

11 papers

NM_000245.4

p.D1231Y

c.3691G>T

2 papers

NM_001127500.3

p.D1249E

c.3747T>A

2 papers

NM_001127500.3

p.D1249E

c.3747T>G

1 paper

NM_000245.4

p.K1232E

c.3694A>G

1 paper

NM_000245.4

p.K1232*

c.3694A>T

18 papers

NM_000245.4

p.Y1230*

c.3690T>A

18 papers

NM_000245.4

p.Y1230*

c.3690T>G

17 papers

NM_000245.4

p.Y1230S

c.3689A>C

1 paper

NM_000245.4

p.K1232T

c.3695A>C

110 papers

NM_000245.4

p.Y1230C

c.3689A>G

NM_001127500.3

p.Y1248C

c.3743A>G

1 paper

NM_000245.4

p.K1232R

c.3695A>G