Varaico: Literature-Extracted Genetic Variants

MGMT

604 papers

RefSeq Summary

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutag...

Pfam Domains

Methyltransf_1Naa 7–83UCSC6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

DNA_binding_1aa 93–174UCSC6-O-methylguanine DNA methyltransferase, DNA binding domain

Gene Aliases

HGNC Name

O-6-methylguanine-DNA methyltransferase

HGNC Alias Name

methylated-DNA--protein-cysteine methyltransferase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_002412.5

p.Y158H

c.472T>C

Surrounding Variants

2 papers

NM_002412.5

p.Y158F

c.473A>T

1 paper

NM_002412.5

p.N157N

c.471C>T

1 paper

NM_002412.5

p.N157T

c.470A>C

1 paper

NM_002412.5

p.S159T

c.475T>A

1 paper

NM_002412.5

p.S159P

c.475T>C

1 paper

NM_002412.5

p.S159Y

c.476C>A

1 paper

NM_002412.5

p.S159F

c.476C>T

16 papers

NM_002412.5

p.G156A

c.467G>C

1 paper

NM_002412.5

p.G156V

c.467G>T

26 papers

NM_002412.5

p.G160R

c.478G>A

1 paper

NM_002412.5

p.G156S

c.466G>A

26 papers

NM_002412.5

p.G160R

c.478G>C