Varaico: Literature-Extracted Genetic Variants

MGMT

604 papers

RefSeq Summary

Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutag...

Pfam Domains

Methyltransf_1Naa 7–83UCSC6-O-methylguanine DNA methyltransferase, ribonuclease-like domain

DNA_binding_1aa 93–174UCSC6-O-methylguanine DNA methyltransferase, DNA binding domain

Gene Aliases

HGNC Name

O-6-methylguanine-DNA methyltransferase

HGNC Alias Name

methylated-DNA--protein-cysteine methyltransferase

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002412.5

p.G173R

c.517G>C

Surrounding Variants

1 paper

NM_002412.5

p.G173D

c.518G>A

3 papers

NM_002412.5

p.R175Q

c.524G>A

2 papers

NM_002412.5

p.A170T

c.508G>A

1 paper

NM_002412.5

p.A170S

c.508G>T

1 paper

NM_002412.5

p.G177G

c.531G>A

1 paper

NM_002412.5

p.K178E

c.532A>G

69 papers

NM_002412.5

p.K178R

c.533A>G

1 paper

NM_002412.5

p.W167L

c.500G>T

1 paper

NM_002412.5

p.P179S

c.535C>T

2 papers

NM_002412.5

p.E166D

c.498A>C

2 papers

NM_002412.5

p.E166D

c.498A>T

2 papers

NM_002412.5

p.E166Q

c.496G>C