Varaico: Literature-Extracted Genetic Variants

NTRK2

558 papers

RefSeq Summary

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of th...

Pfam Domains

LRRNTaa 31–60UCSCLeucine rich repeat N-terminal domain

LRR_8aa 91–150UCSCLeucine rich repeat

LRRCT_2aa 151–195UCSCLeucine rich repeat C-terminal motif

I-setaa 197–283UCSCImmunoglobulin I-set domain

I-setaa 298–377UCSCImmunoglobulin I-set domain

PK_Tyr_Ser-Thraa 538–807UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

neurotrophic receptor tyrosine kinase 2

HGNC Alias Symbol

TRKB

Papers

RefSeq ID

Protein change

DNA change

1–12 of 691 variants

14 papers

NM_006180.6

p.Y434C

c.1301A>G

11 papers

NM_006180.6

p.S167Y

c.500C>A

11 papers

NM_006180.6

p.P204H

c.611C>A

11 papers

NM_006180.6

p.Y722C

c.2165A>G

8 papers

NM_006180.6

p.G639R

c.1915G>A

8 papers

NM_006180.6

p.G639R

c.1915G>C

7 papers

NM_006180.6

p.A203T

c.607G>A

7 papers

NM_006180.6

p.V486I

c.1456G>A

6 papers

NM_006180.6

p.L138F

c.412C>T

5 papers

NM_006180.6

p.W4C

c.12G>C

5 papers

NM_006180.6

p.F633L

c.1897T>C

5 papers

NM_006180.6

p.F633L

c.1899T>A