Varaico: Literature-Extracted Genetic Variants

NTRK2

558 papers

RefSeq Summary

This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of th...

Pfam Domains

LRRNTaa 31–60UCSCLeucine rich repeat N-terminal domain

LRR_8aa 91–150UCSCLeucine rich repeat

LRRCT_2aa 151–195UCSCLeucine rich repeat C-terminal motif

I-setaa 197–283UCSCImmunoglobulin I-set domain

I-setaa 298–377UCSCImmunoglobulin I-set domain

PK_Tyr_Ser-Thraa 538–807UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

neurotrophic receptor tyrosine kinase 2

HGNC Alias Symbol

TRKB

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

8 papers

NM_006180.6

p.G639R

c.1915G>C

Surrounding Variants

8 papers

NM_006180.6

p.G639R

c.1915G>A

1 paper

NM_006180.6

p.H638N

c.1912C>A

1 paper

NM_006180.6

p.M636T

c.1907T>C

1 paper

NM_006180.6

p.N642K

c.1926C>A

1 paper

NM_006180.6

p.N642K

c.1926C>G

1 paper

NM_006180.6

p.E634D

c.1902G>C

1 paper

NM_006180.6

p.E634D

c.1902G>T

1 paper

NM_006180.6

p.E634K

c.1900G>A

5 papers

NM_006180.6

p.F633L

c.1899T>A

5 papers

NM_006180.6

p.F633L

c.1899T>G

1 paper

NM_006180.6

p.L645V

c.1933C>G

5 papers

NM_006180.6

p.F633L

c.1897T>C