Varaico: Literature-Extracted Genetic Variants

OAS1

149 papers

RefSeq Summary

This interferon-induced gene encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein plays a key role in innate cellular antiviral response, and has been implicated in other cel...

Pfam Domains

NTP_transf_2aa 37–134UCSCNucleotidyltransferase domain

OAS1_Caa 163–348UCSC2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus

Gene Aliases

HGNC Name

2'-5'-oligoadenylate synthetase 1

HGNC Previous Symbol

OIAS

Papers

RefSeq ID

Protein change

DNA change

1–12 of 130 variants

18 papers

NM_016816.4

p.G162S

c.484G>A

10 papers

NM_016816.4

p.R361T

c.1082G>C

9 papers

NM_016816.4

p.A76V

c.227C>T

8 papers

NM_016816.4

p.R130H

c.389G>A

7 papers

NM_016816.4

p.A352T

c.1054G>A

5 papers

NM_016816.4

p.R47Q

c.140G>A

5 papers

NM_016816.4

p.I99V

c.295A>G

5 papers

NM_016816.4

p.C109Y

c.326G>A

4 papers

NM_016816.4

p.R47*

c.139C>T

4 papers

NM_016816.4

p.L198V

c.592C>G

4 papers

NM_016816.4

p.V297G

c.890T>G

3 papers

NM_016816.4

p.E143G

c.428A>G