Varaico: Literature-Extracted Genetic Variants

PAK4

112 papers

RefSeq Summary

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nucle...

Pfam Domains

PBDaa 10–66UCSCP21-Rho-binding domain

Pkinaseaa 321–572UCSCProtein kinase domain

Gene Aliases

HGNC Name

p21 (RAC1) activated kinase 4

HGNC Previous Names

p21(CDKN1A)-activated kinase 4; p21 protein (Cdc42/Rac)-activated kinase 4

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005884.5

p.D353Y

c.1057G>T

Surrounding Variants

7 papers

NM_005884.5

p.K350M

c.1049A>T

1 paper

NM_005884.5

p.Q357fs

c.1069_1070fs

1 paper

NM_005884.5

p.Q357Fs

c.1070delinsGCFs

1 paper

NM_005884.5

p.G333D

c.998G>A

1 paper

NM_005884.5

p.T332fs

c.994_995fs

1 paper

NM_005884.5

p.E329D

c.987G>C

1 paper

NM_005884.5

p.E329D

c.987G>T

2 papers

NM_005884.5

p.E329K

c.985G>A

1 paper

NM_005884.5

p.I327L

c.979A>C

1 paper

NM_001014834.3

p.Q150R

c.449A>G

1 paper

NM_005884.5

p.R290C

c.868C>T

1 paper

NM_005884.5

p.A279T

c.835G>A