Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_006218.4

p.E76G

c.227A>G

Surrounding Variants

1 paper

NM_006218.4

p.E76A

c.227A>C

1 paper

NM_006218.4

p.E76V

c.227A>T

1 paper

NM_006218.4

p.E76D

c.228A>C

2 papers

NM_006218.4

p.E76D

c.228A>T

8 papers

NM_006218.4

p.E76K

c.226G>A

5 papers

NM_006218.4

p.E76Q

c.226G>C

1 paper

NM_006218.4

p.Q75Q

c.225A>G

1 paper

NM_006218.4

p.A77T

c.229G>A

1 paper

NM_006218.4

p.A77P

c.229G>C

1 paper

NM_006218.4

p.A77S

c.229G>T

1 paper

NM_006218.4

p.A77E

c.230C>A

2 papers

NM_006218.4

p.A77G

c.230C>G