Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_006218.4

p.L89delFs

c.267delT

Surrounding Variants

1 paper

NM_006218.4

p.L89I

c.265C>A

1 paper

NM_006218.4

p.L89F

c.265C>T

1 paper

NM_006218.4

p.L89_C90delFs

c.266_270del5

1 paper

NM_006218.4

p.L89R

c.266T>G

500 papers

NM_006218.4

p.R88Q

c.263G>A

1 paper

NM_006218.4

p.R88P

c.263G>C

5 papers

NM_006218.4

p.R88L

c.263G>T

1 paper

NM_006218.4

p.C90_D91insFs

c.270_271dupTG

2 papers

NM_006218.4

p.R88G

c.262C>G

6 papers

NM_006218.4

p.R88*

c.262C>T

3 papers

NM_006218.4

p.C90R

c.268T>C

3 papers

NM_006218.4

p.C90G

c.268T>G