Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

38 papers

NM_006218.4

p.R115L

c.344G>T

Surrounding Variants

10 papers

NM_006218.4

p.R115Q

c.344G>A

32 papers

NM_006218.4

p.R115P

c.344G>C

1 paper

NM_006218.4

p.R115insFs

c.344_345insC

1 paper

NM_006218.4

p.R115G

c.343C>G

3 papers

NM_006218.4

p.R115*

c.343C>T

1 paper

NM_006218.4

p.R115_E116del1

c.344_346delGAG

1 paper

NM_006218.4

p.R115_I117delFs

c.344_351del8

3 papers

NM_006218.4

p.E116K

c.346G>A

1 paper

NM_006218.4

p.E116Q

c.346G>C

1 paper

NM_006218.4

p.I117insFs

c.349dupA

1 paper

NM_006218.4

p.E116*

c.346G>T

2 papers

NM_006218.4

p.N114T

c.341A>C