Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.L455L

c.1365G>A

Surrounding Variants

1 paper

NM_006218.4

p.L456M

c.1366C>A

1 paper

NM_006218.4

p.L456fs

c.1366_1367fs

1 paper

NM_006218.4

p.L456V

c.1366C>G

1 paper

NM_006218.4

p.L456L

c.1366C>T

1 paper

NM_006218.4

p.L456fs

c.1366_1367fs

1 paper

NM_006218.4

p.L455S

c.1364T>C

4 papers

NM_006218.4

p.L456R

c.1367T>G

1 paper

NM_006218.4

p.L455_V461del0

c.1365_1382del18

1 paper

NM_006218.4

p.N457del1

c.1369_1370delAAC

1 paper

NM_006218.4

p.N457_N467del11

c.1369_1400del33

2 papers

NM_006218.4

p.L455del1

c.1363_1364delTTG

4 papers

NM_006218.4

p.D454G

c.1361A>G