Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

77 papers

NM_006218.4

p.G914R

c.2740G>C

Surrounding Variants

83 papers

NM_006218.4

p.G914R

c.2740G>A

2 papers

NM_006218.4

p.G914A

c.2741G>C

1 paper

NM_006218.4

p.I913S

c.2738T>G

4 papers

NM_006218.4

p.D915N

c.2743G>A

2 papers

NM_006218.4

p.D915fs

c.2743_2744fs

1 paper

NM_006218.4

p.D915Y

c.2743G>T

1 paper

NM_006218.4

p.D915A

c.2744A>C

2 papers

NM_006218.4

p.D915_R916delFs

c.2745_2746delTC

1 paper

NM_006218.4

p.G912E

c.2735G>A

1 paper

NM_006218.4

p.G912V

c.2735G>T

1 paper

NM_006218.4

p.R916S

c.2746C>A

1 paper

NM_006218.4

p.R916G

c.2746C>G