Varaico: Literature-Extracted Genetic Variants

PIK3CA

10,890 papers

RefSeq Summary

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphor...

Pfam Domains

PI3K_p85Baa 32–107UCSCPI3-kinase family, p85-binding domain

PI3K_rbdaa 173–292UCSCPI3-kinase family, ras-binding domain

PI3K_C2aa 350–485UCSCPhosphoinositide 3-kinase C2

PI3Kaaa 519–704UCSCPhosphoinositide 3-kinase family, accessory domain (PIK domain)

PI3_PI4_kinaseaa 796–1015UCSCPhosphatidylinositol 3- and 4-kinase

Gene Aliases

HGNC Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha

HGNC Alias Symbol

PI3K

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_006218.4

p.H931R

c.2792A>G

Surrounding Variants

1 paper

NM_006218.4

p.H931Y

c.2791C>T

1 paper

NM_006218.4

p.I932V

c.2794A>G

2 papers

NM_006218.4

p.F930S

c.2789T>C

1 paper

NM_006218.4

p.F930V

c.2788T>G

1 paper

NM_006218.4

p.D933Y

c.2797G>T

16 papers

NM_006218.4

p.D933A

c.2798A>C

1 paper

NM_006218.4

p.F934delFs

c.2800delT

1 paper

NM_006218.4

p.L929M

c.2785C>A

1 paper

NM_006218.4

p.D933E

c.2799T>G

2 papers

NM_006218.4

p.F934S

c.2801T>C

2 papers

NM_006218.4

p.H936delins

c.2806_2807delinsGT

1 paper

NM_006218.4

p.H936Q

c.2808C>A