Varaico: Literature-Extracted Genetic Variants

PLK1

358 papers

RefSeq Summary

The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of ...

Pfam Domains

Pkinaseaa 53–305UCSCProtein kinase domain

POLO_boxaa 419–476UCSCPOLO box duplicated region

POLO_boxaa 517–580UCSCPOLO box duplicated region

Gene Aliases

HGNC Name

polo like kinase 1

HGNC Previous Names

polo-like kinase (Drosophila); polo-like kinase 1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005030.6

p.E140Q

c.418G>C

Surrounding Variants

1 paper

NM_005030.6

p.E140D

c.420G>C

1 paper

NM_005030.6

p.E140D

c.420G>T

1 paper

NM_005030.6

p.L138fs

c.412_413fs

7 papers

NM_005030.6

p.S137A

c.409T>G

1 paper

NM_005030.6

p.R136_S137Splc

c.409-1G>T

1 paper

NM_005030.6

p.L138delFs

c.413_414delTC

1 paper

NM_005030.6

p.K146R

c.437A>G

1 paper

NM_005030.6

p.E150Q

c.448G>C

1 paper

NM_005030.6

p.P151L

c.452C>T

1 paper

NM_005030.6

p.E152K

c.454G>A

1 paper

NM_005030.6

p.R154Q

c.461G>A

1 paper

NM_005030.6

p.R154L

c.461G>T