Varaico: Literature-Extracted Genetic Variants

PRKCA

332 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide v...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 339–597UCSCProtein kinase domain

Pkinase_Caa 623–658UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C alpha

HGNC Previous Symbol

PKCA

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002737.3

p.R22H

c.65G>A

Surrounding Variants

1 paper

NM_002737.3

p.G24insFs

c.71dupG

1 paper

NM_002737.3

p.A21T

c.61G>A

1 paper

NM_002737.3

p.F20L

c.60C>A

1 paper

NM_002737.3

p.F20L

c.60C>G

1 paper

NM_002737.3

p.F20I

c.58T>A

1 paper

NM_002737.3

p.F20L

c.58T>C

7 papers

NM_002737.3

p.A25E

c.74C>A

1 paper

NM_002737.3

p.N18H

c.52A>C

1 paper

NM_002737.3

p.L26L

c.78G>A

1 paper

NM_002737.3

p.A17T

c.49G>A

1 paper

NM_002737.3

p.Q28L

c.83A>T

1 paper

NM_002737.3

p.Q14P

c.41A>C