Varaico: Literature-Extracted Genetic Variants

PRKCA

332 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide v...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 339–597UCSCProtein kinase domain

Pkinase_Caa 623–658UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C alpha

HGNC Previous Symbol

PKCA

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

11 papers

NM_002737.3

p.D294G

c.881A>G

Surrounding Variants

1 paper

NM_002737.3

p.D294A

c.881A>C

1 paper

NM_002737.3

p.D294E

c.882C>A

1 paper

NM_002737.3

p.D294E

c.882C>G

2 papers

NM_002737.3

p.D294N

c.880G>A

1 paper

NM_002737.3

p.G293R

c.877G>A

1 paper

NM_002737.3

p.G293R

c.877G>C

1 paper

NM_002737.3

p.E296V

c.887A>T

1 paper

NM_002737.3

p.I290V

c.868A>G

1 paper

NM_002737.3

p.M299I

c.897G>A

1 paper

NM_002737.3

p.M299I

c.897G>C

1 paper

NM_002737.3

p.M299I

c.897G>T

1 paper

NM_002737.3

p.Q303delFs

c.909delG