Varaico: Literature-Extracted Genetic Variants

PRKCB

289 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide varie...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 342–600UCSCProtein kinase domain

Pkinase_Caa 622–662UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C beta

HGNC Previous Symbols

PRKCB2; PKCB; PRKCB1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

3 papers

NM_002738.7

p.R361Q

c.1082G>A

Surrounding Variants

1 paper

NM_002738.7

p.S359T

c.1075T>A

1 paper

NM_002738.7

p.T364R

c.1091C>G

1 paper

NM_002738.7

p.D365E

c.1095T>A

1 paper

NM_002738.7

p.D365E

c.1095T>G

1 paper

NM_002738.7

p.V356F

c.1066G>T

5 papers

NM_002738.7

p.K371R

c.1112A>G

1 paper

NM_002738.7

p.K371M

c.1112A>T

1 paper

NM_002738.7

p.I372_K375delFs

c.1115_1125del11

1 paper

NM_002738.7

p.K374M

c.1121A>T

1 paper

NM_002738.7

p.D376G

c.1127A>G

1 paper

NM_002738.7

p.D376D

c.1128C>T

1 paper

NM_002738.7

p.V378E

c.1133T>A