Varaico: Literature-Extracted Genetic Variants

PRKCB

289 papers

RefSeq Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide varie...

Pfam Domains

C1_1aa 37–89UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C1_1aa 102–154UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

C2aa 171–277UCSCC2 domain

Pkinaseaa 342–600UCSCProtein kinase domain

Pkinase_Caa 622–662UCSCProtein kinase C terminal domain

Gene Aliases

HGNC Name

protein kinase C beta

HGNC Previous Symbols

PRKCB2; PKCB; PRKCB1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002738.7

p.E665K

c.1993G>A

Surrounding Variants

1 paper

NM_002738.7

p.S664A

c.1990T>G

1 paper

NM_002738.7

p.P669R

c.2006C>G

1 paper

NM_002738.7

p.S660C

c.1979C>G

1 paper

NM_002738.7

p.S660F

c.1979C>T

2 papers

NM_002738.7

p.E670K

c.2008G>A

7 papers

NM_002738.7

p.S660A

c.1978T>G

1 paper

NM_002738.7

p.E657K

c.1969G>A

1 paper

NM_002738.7

p.F656L

c.1968C>A

1 paper

NM_002738.7

p.F656L

c.1968C>G

1 paper

NM_002738.7

p.F656L

c.1966T>C

1 paper

NM_002738.7

p.F656V

c.1966T>G

4 papers

NM_002738.7

p.E655K

c.1963G>A