Varaico: Literature-Extracted Genetic Variants

PTPN11

3,412 papers

RefSeq Summary

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell gro...

Pfam Domains

SH2aa 6–81UCSCSH2 domain

SH2aa 112–197UCSCSH2 domain

Y_phosphataseaa 273–520UCSCProtein-tyrosine phosphatase

Gene Aliases

HGNC Name

protein tyrosine phosphatase non-receptor type 11

HGNC Previous Symbol

NS1

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

7 papers

NM_002834.5

p.G13R

c.37G>C

Surrounding Variants

3 papers

NM_002834.5

p.G13S

c.37G>A

17 papers

NM_002834.5

p.G13C

c.37G>T

27 papers

NM_002834.5

p.G13D

c.38G>A

4 papers

NM_002834.5

p.G13A

c.38G>C

1 paper

NM_002834.5

p.G13insFs

c.38_39insAT

7 papers

NM_002834.5

p.G13V

c.38G>T

1 paper

NM_002834.5

p.T12T

c.36T>A

1 paper

NM_002834.5

p.T12N

c.35C>A

1 paper

NM_002834.5

p.T12insFs

c.35_36insG

2 papers

NM_002834.5

p.T12S

c.35C>G

2 papers

NM_002834.5

p.T12delins

c.35_36delinsTT

1 paper

NM_002834.5

p.T12delins

c.35_36delinsTA