Varaico: Literature-Extracted Genetic Variants

Gene:PTTG1
Variant:p.D199N

PTTG1

113 papers

RefSeq Summary

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with ...

Pfam Domains

Securinaa 1–191UCSCSecurin sister-chromatid separation inhibitor

Gene Aliases

HGNC Name

PTTG1 regulator of sister chromatid separation, securin

HGNC Previous Symbol

TUTR1

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_004219.4
p.D199N
c.595G>A
Surrounding Variants
1 paper
NM_004219.4
p.S187A
c.559T>G
2 papers
NM_004219.4
p.S184G
c.550A>G
2 papers
NM_004219.4
p.S183A
c.547T>G
1 paper
NM_004219.4
p.P182A
c.544C>G
2 papers
NM_004219.4
p.S181A
c.541T>G
1 paper
NM_004219.4
p.L179V
c.535T>G
1 paper
NM_004219.4
p.S176A
c.526T>G
1 paper
NM_004219.4
p.P173L
c.518C>T
1 paper
NM_004219.4
p.P172A
c.514C>G
1 paper
NM_004219.4
p.S171A
c.511T>G
3 papers
NM_004219.4
p.P170L
c.509C>T
1 paper
NM_004219.4
p.P166L
c.497C>T
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