Varaico: Literature-Extracted Genetic Variants

RAF1

1,521 papers

RefSeq Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to w...

Pfam Domains

RBDaa 57–131UCSCRaf-like Ras-binding domain

C1_1aa 139–187UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 349–606UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

Raf-1 proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

Raf-1; c-Raf; CRAF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002880.4

p.S621P

c.1861T>C

Surrounding Variants

28 papers

NM_002880.4

p.S621A

c.1861T>G

1 paper

NM_002880.4

p.S621T

c.1861T>A

1 paper

NM_002880.4

p.E622K

c.1864G>A

1 paper

NM_002880.4

p.A620T

c.1858G>A

2 papers

NM_002880.4

p.R618Q

c.1853G>A

2 papers

NM_002880.4

p.S624A

c.1870T>G

2 papers

NM_002880.4

p.N617S

c.1850A>G

1 paper

NM_002880.4

p.I616T

c.1847T>C

2 papers

NM_002880.4

p.H626R

c.1877A>G

1 paper

NM_002880.4

p.R627W

c.1879C>T

1 paper

NM_002880.4

p.R627Q

c.1880G>A

1 paper

NM_002880.4

p.P614L

c.1841C>T