Varaico: Literature-Extracted Genetic Variants

RAF1

1,521 papers

RefSeq Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to w...

Pfam Domains

RBDaa 57–131UCSCRaf-like Ras-binding domain

C1_1aa 139–187UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 349–606UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

Raf-1 proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

Raf-1; c-Raf; CRAF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002880.4

p.N552D

c.1654A>G

Surrounding Variants

1 paper

NM_002880.4

p.I551M

c.1653C>G

1 paper

NM_002880.4

p.N552S

c.1655A>G

1 paper

NM_002880.4

p.N553H

c.1657A>C

1 paper

NM_002880.4

p.H550N

c.1648C>A

1 paper

NM_002880.4

p.R554Q

c.1661G>A

1 paper

NM_002880.4

p.S549F

c.1646C>T

1 paper

NM_002880.4

p.E545G

c.1634A>G

3 papers

NM_002880.4

p.E545A

c.1634A>C

1 paper

NM_002880.4

p.E545Q

c.1633G>C

14 papers

NM_002880.4

p.E545K

c.1633G>A

1 paper

NM_002880.4

p.Q556_I557Splc

c.1668+7C>T

1 paper

NM_002880.4

p.G544G

c.1632G>C