Varaico: Literature-Extracted Genetic Variants

RAF1

1,521 papers

RefSeq Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to w...

Pfam Domains

RBDaa 57–131UCSCRaf-like Ras-binding domain

C1_1aa 139–187UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 349–606UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

Raf-1 proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

Raf-1; c-Raf; CRAF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002880.4

p.A490V

c.1469C>T

Surrounding Variants

1 paper

NM_002880.4

p.A490T

c.1468G>A

4 papers

NM_002880.4

p.L489F

c.1467G>T

4 papers

NM_002880.4

p.L489F

c.1467G>C

6 papers

NM_002880.4

p.T491A

c.1471A>G

1 paper

NM_002880.4

p.L489S

c.1466T>C

20 papers

NM_002880.4

p.T491I

c.1472C>T

12 papers

NM_002880.4

p.T491R

c.1472C>G

2 papers

NM_002880.4

p.V492fs

c.1474_1475fs

3 papers

NM_002880.4

p.V492E

c.1475T>A

2 papers

NM_002880.4

p.T491_V492delFs

c.1473_1474delCT

1 paper

NM_002880.4

p.K493R

c.1478A>G

6 papers

NM_002880.4

p.S494A

c.1480T>G