Varaico: Literature-Extracted Genetic Variants

RAF1

1,521 papers

RefSeq Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to w...

Pfam Domains

RBDaa 57–131UCSCRaf-like Ras-binding domain

C1_1aa 139–187UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 349–606UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

Raf-1 proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

Raf-1; c-Raf; CRAF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

10 papers

NM_002880.4

p.D486G

c.1457A>G

Surrounding Variants

6 papers

NM_002880.4

p.D486A

c.1457A>C

1 paper

NM_002880.4

p.D486E

c.1458T>G

1 paper

NM_002880.4

p.D486E

c.1458T>A

16 papers

NM_002880.4

p.D486N

c.1456G>A

1 paper

NM_002880.4

p.I484V

c.1450A>G

1 paper

NM_002880.4

p.L489S

c.1466T>C

1 paper

NM_002880.4

p.K483T

c.1448A>C

4 papers

NM_002880.4

p.L489F

c.1467G>T

4 papers

NM_002880.4

p.L489F

c.1467G>C

1 paper

NM_002880.4

p.K483E

c.1447A>G

1 paper

NM_002880.4

p.K483Q

c.1447A>C

1 paper

NM_002880.4

p.A490T

c.1468G>A