Varaico: Literature-Extracted Genetic Variants

RAF1

1,521 papers

RefSeq Summary

This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to w...

Pfam Domains

RBDaa 57–131UCSCRaf-like Ras-binding domain

C1_1aa 139–187UCSCPhorbol esters/diacylglycerol binding domain (C1 domain)

PK_Tyr_Ser-Thraa 349–606UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

Raf-1 proto-oncogene, serine/threonine kinase

HGNC Alias Symbols

Raf-1; c-Raf; CRAF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_002880.4

p.S338*

c.1013C>G

Surrounding Variants

1 paper

NM_002880.4

p.S338*

c.1013C>A

25 papers

NM_002880.4

p.S338A

c.1012T>G

2 papers

NM_002880.4

p.S339N

c.1016G>A

34 papers

NM_002880.4

p.Y340D

c.1018T>G

9 papers

NM_002880.4

p.Y340F

c.1019A>T

35 papers

NM_002880.4

p.Y341D

c.1021T>G

8 papers

NM_002880.4

p.Q335H

c.1005G>T

8 papers

NM_002880.4

p.Q335H

c.1005G>C

11 papers

NM_002880.4

p.Y341F

c.1022A>T

1 paper

NM_002880.4

p.Y341*

c.1023T>G

1 paper

NM_002880.4

p.Y341*

c.1023T>A

1 paper

NM_002880.4

p.Q335fs

c.1003_1004fs