Varaico: Literature-Extracted Genetic Variants

ROS1

967 papers

RefSeq Summary

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integ...

Pfam Domains

fn3aa 206–290UCSCFibronectin type III domain

Fn3_ROS1aa 1438–1548UCSCROS1, fibronectin type III domain

fn3aa 1657–1741UCSCFibronectin type III domain

PK_Tyr_Ser-Thraa 1939–2209UCSCProtein tyrosine and serine/threonine kinase

Gene Aliases

HGNC Name

ROS proto-oncogene 1, receptor tyrosine kinase

HGNC Alias Symbols

MCF3; c-ros-1

Papers

RefSeq ID

Protein change

DNA change

1–12 of 850 variants

25 papers

NM_001378902.1

p.R240K

c.719G>A

24 papers

NM_001378902.1

p.G719A

c.2156G>C

22 papers

NM_001378902.1

p.G719S

c.2155G>A

15 papers

NM_001378902.1

p.Q1353P

c.4058A>C

15 papers

NM_001378902.1

p.E1902K

c.5704G>A

14 papers

NM_001378902.1

p.G719C

c.2155G>T

13 papers

NM_001378902.1

p.V157M

c.469G>A

13 papers

NM_001378902.1

p.R240T

c.719G>C

11 papers

NM_001378902.1

p.N2228H

c.6682A>C

7 papers

NM_001378902.1

p.S382P

c.1144T>C

7 papers

NM_001378902.1

p.L833V

c.2497T>G

6 papers

NM_001378902.1

p.E1239V

c.3716A>T