Varaico: Literature-Extracted Genetic Variants

Gene:SHC1
Variant:p.E33G

SHC1

234 papers

RefSeq Summary

This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in ...

Pfam Domains

PIDaa 162–318UCSCPhosphotyrosine interaction domain (PTB/PID)
SH2aa 488–559UCSCSH2 domain

Gene Aliases

HGNC Name

SHC adaptor protein 1

HGNC Alias Symbols

p66; ShcA

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
6 papers
NM_001130040.2
p.E33G
c.98A>G
Surrounding Variants
1 paper
NM_001130040.2
p.E32V
c.95A>T
2 papers
NM_001130040.2
p.P31fs
c.91_92fs
3 papers
NM_001130040.2
p.P31delFs
c.92delG
7 papers
NM_001130040.2
p.P31L
c.92C>T
1 paper
NM_001130040.2
p.P31fs
c.91_92fs
3 papers
NM_001130040.2
p.S36A
c.106T>G
1 paper
NM_001130040.2
p.S36delFs
c.106delA
1 paper
NM_001130040.2
p.P37T
c.109C>A
1 paper
NM_001130040.2
p.S38S
c.114A>T
1 paper
NM_001130040.2
p.S38S
c.114A>G
1 paper
NM_001130040.2
p.A39G
c.116C>G
1 paper
NM_001130040.2
p.G43E
c.128G>A
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