Varaico: Literature-Extracted Genetic Variants

SOS1

956 papers

RefSeq Summary

This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding ...

Pfam Domains

RhoGEFaa 211–388UCSCRhoGEF domain

SOS1_NGEF_PHaa 439–544UCSCSOS1/NGEF-like PH domain

RasGEF_Naa 600–717UCSCRasGEF N-terminal motif

RasGEFaa 783–962UCSCRasGEF domain

Gene Aliases

HGNC Name

SOS Ras/Rac guanine nucleotide exchange factor 1

HGNC Previous Symbol

GINGF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_005633.4

p.Q5Q

c.15G>A

Surrounding Variants

1 paper

NM_005633.4

p.L6insFs

c.17_18insT

12 papers

NM_005633.4

p.Q4H

c.12G>C

19 papers

NM_005633.4

p.Q4Q

c.12G>A

1 paper

NM_005633.4

p.A3E

c.8C>A

1 paper

NM_005633.4

p.Q2*

c.4C>T

1 paper

NM_005633.4

p.M1insFs

c.2dupT

1 paper

NM_005633.4

p.M1_Q2insFs

c.3_4insA

1 paper

NM_005633.4

p.E9insFs

c.27dupG

1 paper

NM_005633.4

p.M1K

c.2T>A

2 papers

NM_005633.4

p.M1V

c.1A>G

1 paper

NM_005633.4

p.M1L

c.1A>C

2 papers

NM_005633.4

p.S12I

c.35G>T