Varaico: Literature-Extracted Genetic Variants

STAT1

1,286 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 143–309UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 321–458UCSCSTAT protein, DNA binding domain

STAT_linkeraa 480–558UCSCSignal transducer and activator of transcription, linker domain

SH2aa 573–651UCSCSH2 domain

STAT1_TAZ2bindaa 715–739UCSCSTAT1 TAZ2 binding domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 1

HGNC Alias Symbols

STAT91; ISGF-3

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

7 papers

NM_007315.4

p.T385K

c.1154C>A

Surrounding Variants

98 papers

NM_007315.4

p.T385M

c.1154C>T

1 paper

NM_007315.4

p.T385insFs

c.1154_1155ins5

1 paper

NM_007315.4

p.T385T

c.1155G>A

7 papers

NM_007315.4

p.T385A

c.1153A>G

1 paper

NM_007315.4

p.H386insFs

c.1156_1157insT

1 paper

NM_007315.4

p.G384V

c.1151G>T

3 papers

NM_007315.4

p.G384A

c.1151G>C

13 papers

NM_007315.4

p.G384D

c.1151G>A

3 papers

NM_007315.4

p.G384C

c.1150G>T

2 papers

NM_007315.4

p.G384S

c.1150G>A

11 papers

NM_007315.4

p.T387A

c.1159A>G

1 paper

NM_007315.4

p.T387I

c.1160C>T