Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_139276.3

p.P725L

c.2174C>T

Surrounding Variants

1 paper

NM_139276.3

p.L724delFs

c.2170delG

1 paper

NM_139276.3

p.M726I

c.2178G>T

1 paper

NM_139276.3

p.M726I

c.2178G>C

1 paper

NM_139276.3

p.M726I

c.2178G>A

77 papers

NM_139276.3

p.S727A

c.2179T>G

2 papers

NM_139276.3

p.S727P

c.2179T>C

1 paper

NM_139276.3

p.S727Y

c.2180C>A

2 papers

NM_139276.3

p.D723H

c.2167G>C

1 paper

NM_139276.3

p.I722M

c.2166T>G

1 paper

NM_139276.3

p.I722S

c.2165T>G

1 paper

NM_139276.3

p.I722delFs

c.2164delT

2 papers

NM_139276.3

p.R729fs

c.2185_2186fs