Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

38 papers

NM_139276.3

p.T716M

c.2147C>T

Surrounding Variants

1 paper

NM_139276.3

p.T716T

c.2148G>A

1 paper

NM_139276.3

p.T716A

c.2146A>G

4 papers

NM_139276.3

p.T717A

c.2149A>G

37 papers

NM_139276.3

p.P715L

c.2144C>T

NM_003150.4

p.P714L

c.2141C>T

2 papers

NM_139276.3

p.P715R

c.2144C>G

1 paper

NM_139276.3

p.P715Q

c.2144C>A

1 paper

NM_139276.3

p.P715S

c.2143C>T

2 papers

NM_139276.3

p.P715A

c.2143C>G

1 paper

NM_139276.3

p.P715T

c.2143C>A

1 paper

NM_139276.3

p.S719G

c.2155A>G

1 paper

NM_139276.3

p.S719T

c.2156G>C

1 paper

NM_139276.3

p.S719N

c.2156G>A