Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_139276.3

p.D676Y

c.2026G>T

Surrounding Variants

1 paper

NM_139276.3

p.Y674D

c.2020T>G

2 papers

NM_139276.3

p.P678S

c.2032C>T

1 paper

NM_139276.3

p.P678fs

c.2032_2033fs

1 paper

NM_139276.3

p.P678delFs

c.2034delG

1 paper

NM_139276.3

p.Y672C

c.2015A>G

2 papers

NM_139276.3

p.E680A

c.2039A>C

4 papers

NM_139276.3

p.V671F

c.2011G>T

1 paper

NM_139276.3

p.V671L

c.2011G>C

2 papers

NM_139276.3

p.E681K

c.2041G>A

1 paper

NM_139276.3

p.E681V

c.2042A>T

14 papers

NM_139276.3

p.S668F

c.2003C>T

10 papers

NM_139276.3

p.S668Y

c.2003C>A