Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_139276.3

p.K642R

c.1925A>G

Surrounding Variants

16 papers

NM_139276.3

p.K642E

c.1924A>G

6 papers

NM_139276.3

p.Q643K

c.1927C>A

1 paper

NM_139276.3

p.T641insFs

c.1921_1922insA

1 paper

NM_139276.3

p.Q643R

c.1928A>G

2 papers

NM_139276.3

p.Q643H

c.1929G>T

1 paper

NM_139276.3

p.Q643insFs

c.1928_1929insA

2 papers

NM_139276.3

p.Q643H

c.1929G>C

203 papers

NM_139276.3

p.Y640F

c.1919A>T

1 paper

NM_139276.3

p.Q644R

c.1931A>G

10 papers

NM_139276.3

p.Q644P

c.1931A>C

1 paper

NM_139276.3

p.Y640H

c.1918T>C

1 paper

NM_139276.3

p.Y640N

c.1918T>A