Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

9 papers

NM_139276.3

p.T620S

c.1858A>T

Surrounding Variants

13 papers

NM_139276.3

p.T620A

c.1858A>G

1 paper

NM_139276.3

p.T620I

c.1859C>T

10 papers

NM_139276.3

p.T620S

c.1859C>G

17 papers

NM_139276.3

p.F621V

c.1861T>G

13 papers

NM_139276.3

p.F621L

c.1861T>C

2 papers

NM_139276.3

p.F621I

c.1861T>A

5 papers

NM_139276.3

p.F621S

c.1862T>C

1 paper

NM_139276.3

p.G618V

c.1853G>T

7 papers

NM_139276.3

p.G618A

c.1853G>C

14 papers

NM_139276.3

p.G618D

c.1853G>A

2 papers

NM_139276.3

p.E616_G617del2

c.1846_1850del6

13 papers

NM_139276.3

p.F621L

c.1863C>G