Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

4 papers

NM_139276.3

p.F408L

c.1224C>A

Surrounding Variants

4 papers

NM_139276.3

p.F408L

c.1224C>G

1 paper

NM_139276.3

p.F408S

c.1223T>C

1 paper

NM_139276.3

p.K409Q

c.1225A>C

5 papers

NM_139276.3

p.F408L

c.1222T>C

1 paper

NM_139276.3

p.F408I

c.1222T>A

1 paper

NM_139276.3

p.H410Y

c.1228C>T

1 paper

NM_139276.3

p.E407K

c.1219G>A

16 papers

NM_139276.3

p.H410R

c.1229A>G

2 papers

NM_139276.3

p.H410P

c.1229A>C

3 papers

NM_139276.3

p.A406V

c.1217C>T

1 paper

NM_139276.3

p.A406T

c.1216G>A

1 paper

NM_139276.3

p.L411F

c.1233G>T