Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

26 papers

NM_139276.3

p.F384L

c.1150T>C

Surrounding Variants

3 papers

NM_139276.3

p.F384C

c.1151T>G

14 papers

NM_139276.3

p.F384S

c.1151T>C

2 papers

NM_139276.3

p.F384Y

c.1151T>A

26 papers

NM_139276.3

p.F384L

c.1152T>G

27 papers

NM_139276.3

p.F384L

c.1152T>A

1 paper

NM_139276.3

p.N385H

c.1153A>C

15 papers

NM_139276.3

p.R382L

c.1145G>T

4 papers

NM_139276.3

p.R382P

c.1145G>C

91 papers

NM_139276.3

p.R382Q

c.1145G>A

132 papers

NM_139276.3

p.R382W

c.1144C>T

5 papers

NM_139276.3

p.R382G

c.1144C>G

2 papers

NM_139276.3

p.I386T

c.1157T>C