Varaico: Literature-Extracted Genetic Variants

STAT3

2,222 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and the...

Pfam Domains

STAT_intaa 2–120UCSCSTAT protein, protein interaction domain

STAT_alphaaa 113–281UCSCSTAT transcription factor, coiled-coil domain

STAT_alphaaa 145–313UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 325–464UCSCSTAT protein, DNA binding domain

STAT_linkeraa 486–565UCSCSignal transducer and activator of transcription, linker domain

SH2aa 584–674UCSCSH2 domain

Gene Aliases

HGNC Name

signal transducer and activator of transcription 3

HGNC Alias Symbol

APRF

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_139276.3

p.S381fs

c.1141_1142fs

Surrounding Variants

1 paper

NM_139276.3

p.S381P

c.1141T>C

1 paper

NM_139276.3

p.S381F

c.1142C>T

3 papers

NM_139276.3

p.S381Y

c.1142C>A

4 papers

NM_139276.3

p.G380R

c.1138G>C

4 papers

NM_139276.3

p.G380R

c.1138G>A

132 papers

NM_139276.3

p.R382W

c.1144C>T

5 papers

NM_139276.3

p.R382G

c.1144C>G

1 paper

NM_139276.3

p.G380Splc

c.1140-2A>G

4 papers

NM_139276.3

p.G380Splc

c.1140-2A>C

15 papers

NM_139276.3

p.R382L

c.1145G>T

4 papers

NM_139276.3

p.R382P

c.1145G>C

91 papers

NM_139276.3

p.R382Q

c.1145G>A