Varaico: Literature-Extracted Genetic Variants

STAT6

483 papers

RefSeq Summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated...

Pfam Domains

STAT_intaa 2–114UCSCSTAT protein, protein interaction domain

STAT_alphaaa 148–262UCSCSTAT transcription factor, coiled-coil domain

STAT_bindaa 277–413UCSCSTAT protein, DNA binding domain

STAT_linkeraa 435–518UCSCSignal transducer and activator of transcription, linker domain

SH2aa 537–616UCSCSH2 domain

STAT6_Caa 655–847UCSCSTAT6 C-terminal

Gene Aliases

HGNC Name

signal transducer and activator of transcription 6

HGNC Alias Symbols

D12S1644; IL-4-STAT

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003153.5

p.I539T

c.1616T>C

Surrounding Variants

1 paper

NM_003153.5

p.S543G

c.1627A>G

8 papers

NM_003153.5

p.V547A

c.1640T>C

7 papers

NM_003153.5

p.T548A

c.1642A>G

1 paper

NM_003153.5

p.E554K

c.1660G>A

1 paper

NM_003153.5

p.E554insFs

c.1661_1662insA

1 paper

NM_003153.5

p.P555L

c.1664C>T

2 papers

NM_003153.5

p.R536Splc

c.1608-41A>C

1 paper

NM_003153.5

p.L561P

c.1682T>C

3 papers

NM_003153.5

p.R562H

c.1685G>A

1 paper

NM_003153.5

p.F563L

c.1687T>C

1 paper

NM_003153.5

p.F563L

c.1689C>G

1 paper

NM_003153.5

p.F563L

c.1689C>A