Varaico: Literature-Extracted Genetic Variants

Gene:TLR2
Variant:p.D299E

TLR2

1,316 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 76–135UCSCLeucine rich repeat
LRRCTaa 561–586UCSCLeucine rich repeat C-terminal domain
TIRaa 640–783UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 2

HGNC Alias Symbols

TIL4; CD282

Papers
RefSeq ID
Protein change
DNA change
Selected Variant
1 paper
NM_001318789.2
p.D299E
c.897T>A
Surrounding Variants
1 paper
NM_001318789.2
p.D299E
c.897T>G
44 papers
NM_001318789.2
p.D299G
c.896A>G
1 paper
NM_001318789.2
p.D299N
c.895G>A
1 paper
NM_001318789.2
p.D301H
c.901G>C
1 paper
NM_001318789.2
p.R296S
c.888A>C
1 paper
NM_001318789.2
p.R296S
c.888A>T
1 paper
NM_001318789.2
p.V303A
c.908T>C
1 paper
NM_001318789.2
p.N294S
c.881A>G
2 papers
NM_001318789.2
p.D305V
c.914A>T
1 paper
NM_001318789.2
p.G293R
c.877G>C
1 paper
NM_001318789.2
p.K308E
c.922A>G
1 paper
NM_001318789.2
p.N290K
c.870T>G
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