Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

2 papers

NM_003265.3

p.S258G

c.772A>G

Surrounding Variants

2 papers

NM_003265.3

p.T262A

c.784A>G

1 paper

NM_003265.3

p.S254P

c.760T>C

2 papers

NM_003265.3

p.T267I

c.800C>T

1 paper

NM_003265.3

p.T248A

c.742A>G

1 paper

NM_003265.3

p.L271_L276del0

c.811_828del18

2 papers

NM_003265.3

p.K240T

c.719A>C

5 papers

NM_003265.3

p.T277P

c.829A>C

1 paper

NM_003265.3

p.T238K

c.713C>A

1 paper

NM_003265.3

p.T238R

c.713C>G

6 papers

NM_003265.3

p.D280N

c.838G>A

1 paper

NM_003265.3

p.N284S

c.851A>G

20 papers

NM_003265.3

p.N284I

c.851A>T