Varaico: Literature-Extracted Genetic Variants

TLR3

639 papers

RefSeq Summary

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved ...

Pfam Domains

LRR_8aa 51–111UCSCLeucine rich repeat

LRR_8aa 274–332UCSCLeucine rich repeat

LRR_8aa 562–622UCSCLeucine rich repeat

Tlr3_TMDaa 698–730UCSCToll-like receptor 3 trans-membrane domain

TIRaa 755–895UCSCTIR domain

Gene Aliases

HGNC Name

toll like receptor 3

HGNC Alias Symbol

CD283

Papers

RefSeq ID

Protein change

DNA change

Selected Variant

1 paper

NM_003265.3

p.S392G

c.1174A>G

Surrounding Variants

2 papers

NM_003265.3

p.R394*

c.1180C>T

2 papers

NM_003265.3

p.R394Q

c.1181G>A

1 paper

NM_003265.3

p.S389_F390insFs

c.1167_1168insC

1 paper

NM_003265.3

p.E399_T400delins

c.1196_1198delinsTTT

1 paper

NM_003265.3

p.L384*

c.1151T>A

1 paper

NM_003265.3

p.L384*

c.1151T>G

1 paper

NM_003265.3

p.L381P

c.1142T>C

1 paper

NM_003265.3

p.G377E

c.1130G>A

1 paper

NM_003265.3

p.T376R

c.1127C>G

4 papers

NM_003265.3

p.M374T

c.1121T>C

5 papers

NM_003265.3

p.L412V

c.1234C>G

206 papers

NM_003265.3

p.L412F

c.1234C>T